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  • Clinical and Scientific Data
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Question

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Subtitle

VMS can impact: Button Space S

Women living with VMS reported a negative impact on sleep (82%), mood (69%), concentration (69%), energy (63%), sexual activity (41%), work (46%), social activities (44%), and leisure activities (48%).1

Question

Correct Answer

How likely are severe VMS to cause a negative impact on overall quality of life compared to mild or moderate symptoms? Button Space XL

3.6x. Women with severe VMS were 3.58 times as likely to be negatively impacted as those with mild/moderate symptoms.1

Question

Correct Answer

VMS may be an indicator of future chronic conditions.Button Space L

True. Recent studies have shown that the frequency and severity of VMS can be used as a biomarker for chronic disease in the future, such as cognitive impairment, cardiovascular disease, and bone health.Severe. 

Question

Correct Answer

Waking up in the middle of the night due to VMS, feeling hot with a damp pillowcase, is classified as what severity of VMS?  Button Space M

Severe. A severe VMS episode is defined as the sensation of heat with sweating causing cessation of activity (such as sleeping)3

Question

Correct Answer

Sleep disturbances due to VMS are one of the most bothersome aspects of the menopausal transition.

True. 40% to 60% of women report sleep disturbances during the menopausal transition, including nighttime awakenings.4

Question

Correct Answer

VMS may be an indicator of future chronic conditions.Button Space L

True. Recent studies have shown that the frequency and severity of VMS can be used as a biomarker for chronic disease in the future, such as cognitive impairment, cardiovascular disease, and bone health.Severe. 

Question

Correct Answer

How long do women typically experience hot flashes and night sweats? 

Women experience VMS for a median duration of 7.4 years. However, some women may experience symptoms for 10 or more years.6

Question

Correct Answer

Approximately what percentage of women experience Vasomotor Symptoms (VMS), also known as hot flashes and night sweats, during the menopausal transition?

In the US, up to 80% of women experience VMS during the menopausal transition.3

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  1. Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T. Symptoms of menopause - global prevalence, physiology and implications. Nat Rev Endocrinol 2018;14(4):199-215.
  2. Thurston RC. Vasomotor symptoms. In: Crandall CJ, Bachman GA, Faubion SS, et al., eds. Menopause Practice: A Clinician's Guide. 6th ed. Pepper Pike, OH: The North American Menopause Society, 2019;43-55.
  3. Padilla SL, Johnson CW, Barker FD, Patterson MA, Palmiter RD. A neural circuit underlying the generation of hot flushes. Cell Rep 2018;24(2):271-7.
  4. Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE. Estradiol alters body temperature regulation in the female mouse. Temperature 2018;5(1):56-69.
  5. Krajewski-Hall SJ, Miranda Dos Santos F, McMullen NT, Blackmore EM, Rance NE. Glutamatergic neurokinin 3 receptor neurons in the median preoptic nucleus modulate heat-defense pathways in female mice. Endocrinology 2019;160(4):803-16.

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The front of the Burden of VMS flashcard

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VMS in her words
  • Landscape
  • clinical efficacy
  • convenience

VMS in her words

MAT_ABC_NON_2023-00086

Burden of VMS brochure 4 column image

Diagnosis

Friday 11 17 2023 03:42 AM Thursday 11 30 2023 03:42 AM PST

Find out more about the impacts that VMS have on women. Oestrogen and neurokinin B (NKB) modulate KNDy neurons in a delicate balance, contributing to body temperature regulation.

Oestrogen and neurokinin B (NKB) modulate KNDy neurons in a delicate balance, contributing to body temperature regulation. KNDy neurons are stimulated by NKB and inhibited by oestrogen.1,2,3

  • Padilla SL, Johnson CW, Barker FD, Patterson MA, Palmiter RD.
  • A neural circuit underlying the generation of hot flushes. Cell Rep 2018;24(2):271-7.
  • 1.Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE.
  • 2.Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE.
  • 3.Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE.

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Take a quiz about the most bothersome symptoms of menopause
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Watch the Video here

Take a quiz about the most bothersome symptoms of menopause
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Watch the Video here

Take a quiz about the most bothersome symptoms of menopause

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The burden of VMS

VMS in her words

Not an actual patient.

VMS in her words

MAT_ABC_NON_2023-00086

What really gets me about menopause is the hot flushes. Suddenly I'm turning red, and there's nothing I can do about it.

Women experience VMS for a median duration of 7.4 years. However, some women may experience symptoms for 10 or more years.8

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VMS in her words

Not an actual patient.

VMS in her words

MAT_ABC_NON_2023-00086

What really gets me about menopause is the hot flushes. Suddenly I'm turning red, and there's nothing I can do about it.

Women experience VMS for a median duration of 7.4 years. However, some women may experience symptoms for 10 or more years.8

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Credible Treatment Information

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Facts about diagnosis

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Open & Honest Conversations

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Open & Honest Conversations

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Treatment circleSafety doneEfficacy home
Oestrogen therTreatmentapy closeAdverse events include breast tenderness, vaginal bleeding, and bloating.
Includes a boxed warning that refers to stroke, deep vein thrombosis, endometrial cancer,† and dementia‡; oestrogen therapy should not be used for the prevention of cardiovascular disease or dementia circle		Up to 75% reduction and significant reductions in severity done
Oestrogen-progestin therapy circleAdverse events include breast tenderness, vaginal bleeding, and bloating.
Includes a boxed warning that refers to stroke, deep vein thrombosis, pulmonary emboli, myocardial infarction, invasive breast cancer, and dementia‡; oestrogen therapy should not be used for the prevention of cardiovascular disease or dementi
Oestrogen combined with oestrogen agonist/antagonistAevents include infection, pain, arthralgia, and headach.
Includes a boxed warning that refers to stroke, deep vein thrombosis, endometrial cancer,† dementia,‡ and use with additional oestrogen; oestrogen therapy should not be used for the prevention of cardiovascular disease or dementia
∗Concentration and EnergyActivityWork OutMental Stress
ContentConcentration and Energy©Copyright™§ Tsst
Content

Concentration and Energy
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Concentration and Energy ©Table with Icons
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Content

   

∗Concentration and Energy€closeActivity‡circleWork Out®Mental Stress
circleContenthomeConcentration and Energy©Copyright™§ Tsst
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Concentration and Energy
∗		verified
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Concentration and Energydone_all©Table with Icons
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Content

   
∗Concentration and EnergycheckcircleActivity Boldcircle Work OutMental Stress
ContentConcentration and Energy -Bold ©Copyright™§ Tsst
Content

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∗		done_outline
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circleConcentration and Energycircle ©Table with Icons
Content

   
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  done_outline

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The burden of VMS

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The Hypothalamus & VMS

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Current Standard of Care

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The burden of VMS

The Hypothalamus & VMS

Burden of VMS First Nav Title

Current Standard of Care

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The front of the VMS survey tool

VMS survey tool

Use this survey to discuss with patients the current impact of VMS on their lives

The front of the Mechanism of VMS tool

Mechanism of VMS flashcard

Learn about the science behind VMS during the menopausal transition

The front of the Burden of VMS flashcard

Burden of VMS flashcard

Find out more about the impacts that VMS have on women

The front of the Mechanism of VMS tool

Mechanism of VMS flashcard

Learn about the science behind VMS during the menopausal transition

The front of the Burden of VMS flashcard

Burden of VMS flashcard

Find out more about the impacts that VMS have on women

The front of the VMS survey tool

VMS survey tool

Use this form with your patients to discuss the current impact and severity of their VMS

The front of the VMS survey tool

VMS survey tool

Use this survey to discuss with patients the current impact of VMS on their lives

The front of the Mechanism of VMS tool

Mechanism of VMS flashcard

Learn about the science behind VMS during the menopausal transition

The front of the Burden of VMS flashcard

Burden of VMS flashcard

Find out more about the impacts that VMS have on women

The front of the Mechanism of VMS tool

Mechanism of VMS flashcard

Learn about the science behind VMS during the menopausal transition

The front of the Burden of VMS flashcard

Burden of VMS flashcard

Find out more about the impacts that VMS have on women

The front of the VMS survey tool

VMS survey tool

Use this form with your patients to discuss the current impact and severity of their VMS

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