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 Reference List (Hyperlink in Dark- Top & Bottom Spacer Options-XL/L/M/S; Authored-S

  1. Monteleone P, Mascagni G, Giannini A, Genazzani AR, Simoncini T. Symptoms of menopause - global prevalence, physiology and implications. Nat Rev Endocrinol 2018;14(4):199-215.
  2. Thurston RC. Vasomotor symptoms. In: Crandall CJ, Bachman GA, Faubion SS, et al., eds. Menopause Practice: A Clinician's Guide. 6th ed. Pepper Pike, OH: The North American Menopause Society, 2019;43-55.
  3. Padilla SL, Johnson CW, Barker FD, Patterson MA, Palmiter RD. A neural circuit underlying the generation of hot flushes. Cell Rep 2018;24(2):271-7.
  4. Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE. Estradiol alters body temperature regulation in the female mouse. Temperature 2018;5(1):56-69.
  5. Krajewski-Hall SJ, Miranda Dos Santos F, McMullen NT, Blackmore EM, Rance NE. Glutamatergic neurokinin 3 receptor neurons in the median preoptic nucleus modulate heat-defense pathways in female mice. Endocrinology 2019;160(4):803-16.

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The front of the VMS survey tool

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The front of the Mechanism of VMS tool

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The front of the Burden of VMS flashcard

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VMS in her words
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  • clinical efficacy
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VMS in her words

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Burden of VMS brochure 4 column image

Diagnosis

Friday 11 17 2023 03:42 AM Thursday 11 30 2023 03:42 AM PST

Find out more about the impacts that VMS have on women. Oestrogen and neurokinin B (NKB) modulate KNDy neurons in a delicate balance, contributing to body temperature regulation.

Oestrogen and neurokinin B (NKB) modulate KNDy neurons in a delicate balance, contributing to body temperature regulation. KNDy neurons are stimulated by NKB and inhibited by oestrogen.1,2,3  Hyperlink on Light

  • Padilla SL, Johnson CW, Barker FD, Patterson MA, Palmiter RD.
  • A neural circuit underlying the generation of hot flushes. Cell Rep 2018;24(2):271-7.
  • 1.Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE.
  • 2.Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE.
  • 3.Krajewski-Hall SJ, Blackmore EM, McMinn JR, Rance NE.

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The burden of VMS

VMS in her words

Not an actual patient.

VMS in her words

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What really gets me about menopause is the hot flushes. Suddenly I'm turning red, and there's nothing I can do about it.

Women experience VMS for a median duration of 7.4 years. However, some women may experience symptoms for 10 or more years.8

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The burden of VMS

The Hypothalamus & VMS

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Current Standard of Care

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The front of the VMS survey tool

VMS survey tool

Use this survey to discuss with patients the current impact of VMS on their lives

The front of the Mechanism of VMS tool

Mechanism of VMS flashcard

Learn about the science behind VMS during the menopausal transition

The front of the Burden of VMS flashcard

Burden of VMS flashcard

Find out more about the impacts that VMS have on women

The front of the Mechanism of VMS tool

Mechanism of VMS flashcard

Learn about the science behind VMS during the menopausal transition

The front of the Burden of VMS flashcard

Burden of VMS flashcard

Find out more about the impacts that VMS have on women

The front of the VMS survey tool

VMS survey tool

Use this form with your patients to discuss the current impact and severity of their VMS

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Accordion

Menopause is defined as the permanent cessation of menstrual periods. However, the symptoms of menopause can begin before the cessation of menses and extend over several years.1

 

Perimenopause, the transition from the reproductive period to the first year postmenopause, is associated with increasing symptom burden. This is due to the neurochemical changes in the central nervous system, which are associated with Vasomotor Symptoms (VMS), sleep disorders, and depression.1

 

Other symptoms can include changes in body shape related to cardiometabolic changes, musculoskeletal alterations, skin and urogenital atrophy, sexual dysfunction, osteoporosis, and sarcopenia.1

 

The symptoms of menopause not only have a significant effect on quality of life, they also have been associated with the onset of chronic conditions—serving as predictors of future health risks.1